Junior research groups, Lighthouse 3

DiP-PhenoPren

Valuable active ingredients are produced from plant residues: PhenoPren is developing an AI-supported biotechnological approach for the sustainable production of natural product derivatives from agricultural and forestry residues.

Project description

Valuable natural products from plant waste

How can plant residues be transformed into valuable active ingredients? The DiP-PhenoPren project is developing a unique combination of biochemistry, artificial intelligence and biotechnology for this purpose. New active ingredients for pharmaceuticals, medicine and cosmetics are to be derived from lignin and apple pomace by enzymes. This creates sustainable alternatives to chemically synthesized active ingredients, green chemistry, so to speak.

At Martin Luther University Halle-Wittenberg and the Leibniz Institute of Plant Biochemistry, a digital platform is being developed that revolutionizes the identification and design of enzymes. With the help of machine learning, the enzymes can be specifically optimized so that they produce high-quality natural products from plant residues.

A special focus is on practical application: The enzymes developed are to be used in biotechnological processes in order to produce valuable active ingredients in a sustainable and environmentally friendly way. Partners from industry are helping to make the technology usable for specific production processes.

DiP-PhenoPren thus not only strengthens Saxony-Anhalt’s position as an innovation location for sustainable biotechnology, but also creates new economic prospects in the region. At the same time, the project enables the environmentally friendly use of plant side streams, reduces waste and strengthens the regional bioeconomy. The combination of digital enzyme optimization and industrial biotechnology makes the region a pioneer for the bio-based value creation of the future.

Goals

• Development of AI-supported methods for enzyme optimization
• Establishment of a platform for enzymatic prenylation
• Use of agricultural and forestry residues as raw materials
• Production of prenylated natural product derivatives in microbial cell factories
• Optimization of biotechnological production
• Possible founding of a biotech start-up in Saxony-Anhalt

Funding period

01.04.2024 – 31.12.2028
Network coordinator
Dr. Mohamed Nagia
Martin-Luther-Universität Halle-Wittenberg, Institut für Pharmazie
mohamed.nagia@pharmazie.uni-halle.de

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